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DOX is a highly toxic molecule and induces drug resistance due to the overexpression of ABCB1 efflux pump and other related proteins 127

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Limited proteolysis, which results in the accumulation of specific fragments corresponding to the more rigid parts of a protein, is different from the total proteolysis (also through the action of proteases) leading to the complete or near-complete degradation of a protein into its constituent amino acids, which is useful for determination of amino acid sequence